Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients

Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients

Summary: Early responses to vaccination are important for shaping both humoral and cellular protective immunity. Dissecting innate vaccine signatures may predict immunogenicity to help optimize the efficacy of mRNA and other vaccine strategies. Here, we characterize the cytokine and chemokine respon...

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Bibliographic Details
Main Authors: Cristina Bergamaschi, Evangelos Terpos, Margherita Rosati, Matthew Angel, Jenifer Bear, Dimitris Stellas, Sevasti Karaliota, Filia Apostolakou, Tina Bagratuni, Dimitris Patseas, Sentiljana Gumeni, Ioannis P. Trougakos, Meletios A. Dimopoulos, Barbara K. Felber, George N. Pavlakis
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
SARS-CoV-2
mRNA vaccine
innate immunity
IL-15
IFN-γ
cytokines
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721009323

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http://www.sciencedirect.com/science/article/pii/S2211124721009323

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