A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein

A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein

Abstract Renal fibrosis is a major factor in the progression of chronic kidney disease and the final common pathway of kidney injury. Therefore, the effective therapies against renal fibrosis are urgently needed. The objective of this study was to investigate the effect of Am80, a synthetic retinoic...

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Bibliographic Details
Main Authors: Hiroshi Watanabe, Jing Bi, Ryota Murata, Rui Fujimura, Kento Nishida, Tadashi Imafuku, Yuka Nakamura, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-68337-z

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https://doi.org/10.1038/s41598-020-68337-z

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