Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.

Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.

Sepsis patients may die either from an overwhelming systemic immune response and/or from an immunoparalysis-associated lack of anti-bacterial immune defence. We hypothesized that bacterial superantigen-activated T cells may be prevented from contribution into anti-bacterial response due to the inhib...

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Bibliographic Details
Main Authors: Manfred Thiel, Charles C Caldwell, Simone Kreth, Satoshi Kuboki, P Chen, Patrick Smith, Akio Ohta, Alex B Lentsch, Dmitry Lukashev, Michail V Sitkovsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1959117?pdf=render

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http://europepmc.org/articles/PMC1959117?pdf=render

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