Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT.

Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT.

Genome mining at the turn of the millennium uncovered a new family of type II transmembrane serine proteases (TTSPs) that comprises 17 members in humans and 19 in mice. TTSPs phylogenetically belong to one of four subfamilies: matriptase, hepsin/TMPRSS, corin and HAT/DESC. Whereas a wealth of inform...

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Bibliographic Details
Main Authors: Katiuchia Uzzun Sales, John P Hobson, Rebecca Wagenaar-Miller, Roman Szabo, Amber L Rasmussen, Alexandra Bey, Maham F Shah, Alfredo A Molinolo, Thomas H Bugge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3154331?pdf=render

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http://europepmc.org/articles/PMC3154331?pdf=render

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