Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.

by Roman Szabo, Thomas H Bugge
Published 2018-01-01

Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival.

by Roman Szabo, Diane E Peters, Peter Kosa, Eric Camerer, Thomas H Bugge
Published 2014-07-01

Accelerated wound healing by mTOR activation in genetically defined mouse models.

by Cristiane H Squarize, Rogerio M Castilho, Thomas H Bugge, J Silvio Gutkind
Published 2010-05-01

Matriptase zymogen supports epithelial development, homeostasis and regeneration

by Stine Friis, Daniel Tadeo, Sylvain M. Le-Gall, Henrik Jessen Jürgensen, Katiuchia Uzzun Sales, Eric Camerer, Thomas H. Bugge
Published 2017-06-01

Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin.

by Jeffrey M Schafer, Diane E Peters, Thomas Morley, Shihui Liu, Alfredo A Molinolo, Stephen H Leppla, Thomas H Bugge
Published 2011-01-01

Detection of active matriptase using a biotinylated chloromethyl ketone peptide.

by Sine Godiksen, Christoffer Soendergaard, Stine Friis, Jan K Jensen, Jette Bornholdt, Katiuchia Uzzun Sales, Mingdong Huang, Thomas H Bugge, Lotte K Vogel
Published 2013-01-01

CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets

by Henrik J. Jürgensen, Lakmali M. Silva, Oliver Krigslund, Sander van Putten, Daniel H. Madsen, Niels Behrendt, Lars H. Engelholm, Thomas H. Bugge
Published 2019-02-01

Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis.

by Daniel H Madsen, Henrik J Jürgensen, Signe Ingvarsen, Maria C Melander, Reidar Albrechtsen, Andreas Hald, Kenn Holmbeck, Thomas H Bugge, Niels Behrendt, Lars H Engelholm
Published 2013-01-01

Matriptase deletion initiates a Sjögren's syndrome-like disease in mice.

by Hongen Yin, Peter Kosa, Xibao Liu, William D Swaim, Zhennan Lai, Javier Cabrera-Perez, Giovanni Di Pasquale, Indu S Ambudkar, Thomas H Bugge, John A Chiorini
Published 2014-01-01

Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT.

by Katiuchia Uzzun Sales, John P Hobson, Rebecca Wagenaar-Miller, Roman Szabo, Amber L Rasmussen, Alexandra Bey, Maham F Shah, Alfredo A Molinolo, Thomas H Bugge
Published 2011-01-01

Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation.

by Roman Szabo, Katiuchia Uzzun Sales, Peter Kosa, Natalia A Shylo, Sine Godiksen, Karina K Hansen, Stine Friis, J Silvio Gutkind, Lotte K Vogel, Edith Hummler, Eric Camerer, Thomas H Bugge
Published 2012-01-01

Relative expression of KLK5 to LEKTI is associated with aggressiveness of oral squamous cell carcinoma

by Márcia Gaião Alves, Márcio Hideki Kodama, Elaine Zayas Marcelino da Silva, Bruno Belmonte Martinelli Gomes, Rodrigo Alberto Alves da Silva, Gabriel Viliod Vieira, Vani Maria Alves, Carol Kobori da Fonseca, Ana Carolina Santana, Nerry Tatiana Cecílio, Mara Silvia Alexandre Costa, Maria Célia Jamur, Constance Oliver, Thiago Mattar Cunha, Thomas H. Bugge, Paulo Henrique Braz-Silva, Leandro M. Colli, Katiuchia Uzzun Sales
Published 2021-01-01