KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

The endoplasmic reticulum (ER) unfolded protein response (UPRer) pathway plays an important role in helping pancreatic β cells to adapt their cellular responses to environmental cues and metabolic stress. Although altered UPRer gene expression appears in rodent and human type 2 diabetic (T2D) islets...

Full description

Bibliographic Details
Main Authors: Nabil Rabhi, Pierre-Damien Denechaud, Xavier Gromada, Sarah Anissa Hannou, Hongbo Zhang, Talha Rashid, Elisabet Salas, Emmanuelle Durand, Olivier Sand, Amélie Bonnefond, Loic Yengo, Carine Chavey, Caroline Bonner, Julie Kerr-Conte, Amar Abderrahmani, Johan Auwerx, Lluis Fajas, Philippe Froguel, Jean-Sébastien Annicotte
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716303680

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716303680

Similar Items