Neurofibrillary tau depositions emerge with subthreshold cerebral beta-amyloidosis in down syndrome

Neurofibrillary tau depositions emerge with subthreshold cerebral beta-amyloidosis in down syndrome

Introduction: Adults with Down syndrome are genetically predisposed to develop Alzheimer’s disease and accumulate beta-amyloid plaques (Aβ) early in life. While Aβ has been heavily studied in Down syndrome, its relationship with neurofibrillary tau is less understood. The aim of this study was to ev...

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Bibliographic Details
Main Authors: Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Paul A. Ellison, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Marwan N. Sabbagh, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:NeuroImage: Clinical
Subjects:
Down syndrome
Amyloid
Neurofibrillary tau
Early detection
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158221001844

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http://www.sciencedirect.com/science/article/pii/S2213158221001844

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