Blockade of the Adenosine 2A Receptor Mitigates the Cardiomyopathy Induced by Loss of Plakophilin-2 Expression

Blockade of the Adenosine 2A Receptor Mitigates the Cardiomyopathy Induced by Loss of Plakophilin-2 Expression

Background: Mutations in plakophilin-2 (PKP2) are the most common cause of familial Arrhythmogenic Right Ventricular Cardiomyopathy, a disease characterized by ventricular arrhythmias, sudden death, and progressive fibrofatty cardiomyopathy. The relation between loss of PKP2 expression and structura...

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Bibliographic Details
Main Authors: Marina Cerrone, Chantal J. M. van Opbergen, Kabir Malkani, Natasha Irrera, Mingliang Zhang, Toon A. B. Van Veen, Bruce Cronstein, Mario Delmar
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Physiology
Subjects:
arrhythmogenic right ventricular cardiomyopathy
plakophilin-2
adenosine
fibrosis
desmosomes
cardiomyopathy
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01750/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.01750/full

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