Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

Abstract Alzheimer’s disease (AD) is an irreversible, devastating neurodegenerative brain disorder characterized by the loss of neurons and subsequent cognitive decline. Despite considerable progress in the understanding of the pathophysiology of AD, the precise molecular mechanisms that cause the d...

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Bibliographic Details
Main Authors: Melanie Hüttenrauch, Isabella Ogorek, Hans Klafki, Markus Otto, Christine Stadelmann, Sascha Weggen, Jens Wiltfang, Oliver Wirths
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease (AD)
Glycoprotein nonmetastatic melanoma protein B (GPNMB)
Neuroinflammation
Activated microglia
Sporadic AD patients
Transgenic mice
Online Access:http://link.springer.com/article/10.1186/s40478-018-0612-3

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http://link.springer.com/article/10.1186/s40478-018-0612-3

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