Peptide-Based Scaffolds Support Human Cortical Progenitor Graft Integration to Reduce Atrophy and Promote Functional Repair in a Model of Stroke

Peptide-Based Scaffolds Support Human Cortical Progenitor Graft Integration to Reduce Atrophy and Promote Functional Repair in a Model of Stroke

Stem cell transplants offer significant hope for brain repair following ischemic damage. Pre-clinical work suggests that therapeutic mechanisms may be multi-faceted, incorporating bone-fide circuit reconstruction by transplanted neurons, but also protection/regeneration of host circuitry. Here, we e...

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Bibliographic Details
Main Authors: Fahad A. Somaa, Ting-Yi Wang, Jonathan C. Niclis, Kiara F. Bruggeman, Jessica A. Kauhausen, Haoyao Guo, Stuart McDougall, Richard J. Williams, David R. Nisbet, Lachlan H. Thompson, Clare L. Parish
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
neural transplantation
human embryonic stem cells
stroke
hydrogel
self-assembling peptides
cortex
integration
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310628

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http://www.sciencedirect.com/science/article/pii/S2211124717310628

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