A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies.

A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies.

Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The "rules" governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are initially established,...

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Bibliographic Details
Main Authors: David S Shames, Luc Girard, Boning Gao, Mitsuo Sato, Cheryl M Lewis, Narayan Shivapurkar, Aixiang Jiang, Charles M Perou, Young H Kim, Jonathan R Pollack, Kwun M Fong, Chi-Leung Lam, Maria Wong, Yu Shyr, Rita Nanda, Olufunmilayo I Olopade, William Gerald, David M Euhus, Jerry W Shay, Adi F Gazdar, John D Minna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-12-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC1716188?pdf=render

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http://europepmc.org/articles/PMC1716188?pdf=render

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