Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

The GntR superfamily is one of the largest families of transcription factors in prokaryotes. Here the authors combine biophysical analysis and structural biology to dissect the mechanism by which NanR — a GntR-family regulator — binds to its promoter to repress the transcription of genes necessary f...

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Bibliographic Details
Main Authors: Christopher R. Horne, Hariprasad Venugopal, Santosh Panjikar, David M. Wood, Amy Henrickson, Emre Brookes, Rachel A. North, James M. Murphy, Rosmarie Friemann, Michael D. W. Griffin, Georg Ramm, Borries Demeler, Renwick C. J. Dobson
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22253-6

Internet

https://doi.org/10.1038/s41467-021-22253-6

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