Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

Metabolic regulation influences cell proliferation. The influence of pyruvate kinase isoforms on tumor cells has been extensively studied, but whether PKM2 is required for normal cell proliferation is unknown. We examine how PKM2 deletion affects proliferation and metabolism in nontransformed, nonim...

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Main Authors: Lunt, Sophia Y (Author), Muralidhar, Vinayak (Contributor), Israelsen, William J (Author), Newhouse, Lauren (Author), Ogrodzinski, Martin (Author), Xu, Kali (Contributor), Hollern, Daniel P (Author), Bellinger, Gary (Contributor), Christen, Stefan (Author), Elia, Ilaria (Author), Dinh, Anh T (Author), Stephanopoulos, Gregory (Contributor), Manalis, Scott R (Author), Yaffe, Michael B (Author), Andrechek, Eran R (Author), Fendt, Sarah-Maria (Author), Vander Heiden, Matthew G (Author), Hosios, Aaron Marc (Contributor), Gui, Dan Yi (Contributor), Acevedo, Paula N. Marin (Contributor), Dayton, Talya Lucia (Contributor), Lunt, Sophia Y. (Contributor), Dinh, Anh T. (Contributor), Vander Heiden, Matthew G. (Contributor), Manalis, Scott R (Author), Yaffe, Michael B (Author), Hecht, Vivian Chaya (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hecht, Vivian (Contributor), Manalis, Scott R. (Contributor), Yaffe, Michael B. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-02-23T20:26:08Z.
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