The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

Stromal cells within the tumor microenvironment are essential for tumor progression and metastasis. Surprisingly little is known about the factors that drive the transcriptional reprogramming of stromal cells within tumors. We report that the transcriptional regulator heat shock factor 1 (HSF1) is f...

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Main Authors: Scherz-Shouval, Ruth (Author), Santagata, Sandro (Author), Mendillo, Marc L (Author), Sholl, Lynette M (Author), Ben-Aharon, Irit (Author), Beck, Andrew H (Author), Dias-Santagata, Dora (Author), Stemmer, Salomon M (Author), Whitesell, Luke (Author), Koeva, Martina I (Contributor), Lindquist, Susan (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-12-01T18:50:28Z.
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