Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM

The orchestrated action of genes controls complex biological phenotypes, yet the systematic discovery of gene and drug combinations that modulate these phenotypes in human cells is labor intensive and challenging to scale. Here, we created a platform for the massively parallel screening of barcoded...

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Bibliographic Details
Main Authors: Wong, Siu Lun (Contributor), Cui, Cheryl (Contributor), Pregernig, Gabriela (Contributor), Milani, Pamela (Contributor), Choi, Gigi C. G. (Contributor), Adam, Miriam (Contributor), Perli, Samuel D. (Contributor), Kazer, Samuel Weisgurt (Contributor), Gaillard de Saint Germain, Alethe (Contributor), Hermann, Mario (Contributor), Shalek, Alexander K (Contributor), Fraenkel, Ernest (Contributor), Lu, Timothy K (Contributor)
Other Authors: MIT Synthetic Biology Center (Contributor), Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Research Laboratory of Electronics (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2017-01-12T14:34:58Z.
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