Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

High cancer death rates indicate the need for new anticancer therapeutic agents. Approaches to discovering new cancer drugs include target-based drug discovery and phenotypic screening. Here, we identified phosphodiesterase 3A modulators as cell-selective cancer cytotoxic compounds through phenotypi...

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Main Authors: de Waal, Luc (Author), Lewis, Timothy A (Author), Rees, Matthew G (Author), Tsherniak, Aviad (Author), Wu, Xiaoyun (Author), Choi, Peter S (Author), Gechijian, Lara (Author), Hartigan, Christina (Author), Faloon, Patrick W (Author), Hickey, Mark J (Author), Tolliday, Nicola (Author), Carr, Steven A (Author), Clemons, Paul A (Author), Munoz, Benito (Author), Wagner, Bridget K (Author), Shamji, Alykhan F (Author), Schenone, Monica (Author), Burgin, Alex B (Author), Schreiber, Stuart L (Author), Greulich, Heidi (Author), Meyerson, Matthew (Author), Koehler, Angela Nicole (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-02-15T20:57:06Z.
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