Hydrophobic CDR3 residues promote the development of self-reactive T cells

Hydrophobic CDR3 residues promote the development of self-reactive T cells

Studies of individual T cell antigen receptors (TCRs) have shed some light on structural features that underlie self-reactivity. However, the general rules that can be used to predict whether TCRs are self-reactive have not been fully elucidated. Here we found that the interfacial hydrophobicity of...

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Main Authors: Stadinski, Brian D (Author), Shekhar, Karthik (Author), Gómez-Touriño, Iria (Author), Jung, Jonathan (Author), Sasaki, Katsuhiro (Author), Sewell, Andrew K (Author), Peakman, Mark (Author), Chakraborty, Arup K (Contributor), Huseby, Eric S (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-03-22T18:21:00Z.
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