Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers

Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers

The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subu...

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Bibliographic Details
Main Authors: Tsvetkov, Peter (Author), Brune, Zarina (Author), Thiru, Prathapan (Author), Ghandi, Mahmoud (Author), Santagata, Sandro (Author), Whitesell, Luke (Author), Sokol, Ethan Samuel (Contributor), Jin, Dexter X. (Contributor), Gupta, Piyush (Contributor), Lindquist, Susan (Contributor), Garraway, Levi A. (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Garraway, Levi (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2017-09-13T19:30:56Z.
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