PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but therapeutic inhibition of PI3K has only shown limited success in clinical trials. To understand how mutant PIK3CA contributes to cancer cell proliferation, we used genome scale loss-of-function screening in a large...

Full description

Bibliographic Details
Main Authors: Ilic, Nina (Author), Birsoy, Kıvanç (Author), Aguirre, Andrew J. (Author), Singh, Shambhavi (Author), Moody, Susan E. (Author), DeAngelo, Joseph D. (Author), Spardy, Nicole A. (Author), Freinkman, Elizaveta (Author), Weir, Barbara A. (Author), Tsherniak, Aviad (Author), Cowley, Glenn S. (Author), Root, David E. (Author), Asara, John M. (Author), Vazquez, Francisca (Author), Widlund, Hans R. (Author), Hahn, William C. (Author), Kory, Nora (Contributor), Sabatini, David (Contributor), Pacold, Michael Edward (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Pacold, Michael E (Contributor)
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences, 2017-12-22T20:26:06Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items