In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

In vivo interrogation of the function of genes implicated in tumorigenesis is limited by the need to generate and cross germline mutant mice. Here we describe approaches to model colorectal cancer (CRC) and metastasis, which rely on in situ gene editing and orthotopic organoid transplantation in mic...

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Main Authors: Taylor, Martin S. (Author), Sicinska, Ewa T. (Author), Suarez, Yvelisse (Author), Yoo, James (Author), Chen, Lillian (Author), Zukerberg, Lawrence (Author), Katajisto, Pekka (Author), Deshpande, Vikram (Author), Bass, Adam J. (Author), Tsichlis, Philip N. (Author), Roper, Jatin (Contributor), Tammela, Tuomas (Contributor), Cetinbas, Naniye (Contributor), Akkad, Adam (Contributor), Roghanian, Ali (Contributor), Rickelt, Steffen (Contributor), Almeqdadi, Mohammad (Contributor), Oberli, Matthias (Contributor), Sanchez-Rivera, Francisco Javier (Contributor), Park, Yoona K. (Contributor), Liang, Xu (Contributor), Eng, George M. (Contributor), Azimi, Roxana S. (Contributor), Kedrin, Dmitriy (Contributor), Neupane, Rachit (Contributor), Beyaz, Semir (Contributor), Lees, Jacqueline (Contributor), Langer, Robert S. (Contributor), Hynes, Richard O. (Contributor), Chen, Jianzhu (Contributor), Bhutkar, Arjun (Contributor), Jacks, Tyler E. (Contributor), Yilmaz, Omer (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-06-15T19:18:09Z.
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