Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon serial transplantation in animal models, and elimination of this cell population is required for curative therapies. Here, we describe a series of pooled, in vivo RNAi screens to identify essential transcription fa...

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Bibliographic Details
Main Authors: Puram, Rishi V (Author), Kowalczyk, Monika S (Author), de Boer, Carl G (Author), Schneider, Rebekka K (Author), Miller, Peter G (Author), McConkey, Marie (Author), Tothova, Zuzana (Author), Tejero, Héctor (Author), Heckl, Dirk (Author), Järås, Marcus (Author), Chen, Michelle C (Author), Li, Hubo (Author), Tamayo, Alfred (Author), Cowley, Glenn S (Author), Rozenblatt-Rosen, Orit (Author), Al-Shahrour, Fatima (Author), Ebert, Benjamin L (Author), Regev, Aviv (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-07-03T14:49:58Z.
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