Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease

by Kulicke, Ruth, Cowley, Glenn S., Stein, Rachael, Root, David E., Heiman, Myriam, Shema Tirosh, Reut
Published 2015

Cancer Vulnerabilities Unveiled by Genomic Loss

by Nijhawan, Deepak, Zack, Travis I, Ren, Yin, Strickland, Matthew R, Lamothe, Rebecca, Schumacher, Steven E, Tsherniak, Aviad, Besche, Henrike C, Rosenbluh, Joseph, Shehata, Shyemaa, Cowley, Glenn S., Weir, Barbara A, Goldberg, Alfred L, Mesirov, Jill P., Root, David E, Beroukhim, Rameen, Hahn, William C., Bhatia, Sangeeta N
Published 2014

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

by Puram, Rishi V, Kowalczyk, Monika S, de Boer, Carl G, Schneider, Rebekka K, Miller, Peter G, McConkey, Marie, Tothova, Zuzana, Tejero, Héctor, Heckl, Dirk, Järås, Marcus, Chen, Michelle C, Li, Hubo, Tamayo, Alfred, Cowley, Glenn S, Rozenblatt-Rosen, Orit, Al-Shahrour, Fatima, Ebert, Benjamin L, Regev, Aviv
Published 2018

Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Target ID4

by Ren, Yin, von Maltzhan, Geoffrey, Agrawal, Amit, Mesirov, Jill P., Lo, Justin H., Cheung, Hiu Wing, Cowley, Glenn S., Weir, Barbara A., Boehm, Jesse S., Tamayo, Pablo, Karst, Alison M., Liu, Joyce F., Hirsch, Michelle S., Drapkin, Ronny, Root, David E., Fogal, Valentina, Ruoslahti, Erkki, Hahn, William C., Bhatia, Sangeeta N
Published 2014

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

by Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Hahn, William C., Kory, Nora, Sabatini, David, Pacold, Michael Edward
Published 2017

In vivo discovery of immunotherapy targets in the tumour microenvironment

by Zhou, Penghui, Shaffer, Donald R., Alvarez Arias, Diana A., Nakazaki, Yukoh, Pos, Wouter, Torres, Alexis J., Cremasco, Viviana, Dougan, Stephanie K., Cowley, Glenn S., Elpek, Kutlu, Brogdon, Jennifer, Lamb, John, Turley, Shannon J., Ploegh, Hidde, Root, David E., Dranoff, Glenn, Hacohen, Nir, Cantor, Harvey, Wucherpfennig, Kai W., Love, John C
Published 2014

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

by Paolella, Brenton R, Urbanski, Laura M, Alberta, John A, Bandopadhayay, Pratiti, Nichols, Caitlin A, Agarwalla, Pankaj K, Brown, Meredith S, Lamothe, Rebecca, Yu, Yong, Choi, Peter S, Obeng, Esther A, Heckl, Dirk, Vazquez, Francisca, Buhrlage, Sara J, Stiles, Charles D, Reed, Robin, Gibson, William J, Zack, Travis Ian, Wei, Guo, Wang, Belinda, Tsherniak, Aviad, Weir, Barbara A, Root, David, Cowley, Glenn S, Ebert, Benjamin L, Hahn, William, Beroukhim, Rameen
Published 2017

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer

by Possemato, Richard, Marks, Kevin M., Kim, Dohoon, Birsoy, Kivanc, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G., Jha, Abhishek K., Chen, Walter W., Barrett, Francesca G., Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S., Barretina, Jordi, Kalaany, Nada Y., Hsu, Peggy P., Ottina, Kathleen, Chan, Albert M., Yuan, Bingbing B., Garraway, Levi A., Root, David E., Mino-Kenudson, Mari, Brachtel, Elena F., Driggers, Edward M., Shaul, Yoav, Pacold, Michael Edward, Sabatini, David
Published 2012

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

by Ren, Yin, Meyerson, Matthew L., Drapkin, Ronny, Cheung, Hiu Wing, Cowley, Glenn S., Weir, Barbara A., Boehm, Jesse S., Rusin, Scott, Scott, Justine A., East, Alexandra, Ali, Levi D., Lizotte, Patrick H., Wong, Terence C., Jiang, Guozhi, Hsiao, Jessica, Mermel, Craig H., Getz, Gad, Barretina, Jordi, Gopal, Shuba, Tamayo, Pablo, Gould, Joshua, Tsherniak, Aviad, Stransky, Nicolas, Luo, Biao, Mesirov, Jill P., Garraway, Levi A., Lander, Eric S., Root, David E., Hahn, William C., Bhatia, Sangeeta N
Published 2012

In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

by Miller, Peter G, Al-Shahrour, Fatima, Hartwell, Kimberly A., Chu, Lisa P, Jaras, Marcus, Puram, Rishi V, Puissant, Alexandre, Callahan, Kevin P, Ashton, John, McConkey, Marie, Poveromo, Luke P, Cowley, Glenn S., Kharas, Michael G., Labelle, Myriam, Shterental, Sebastian, Fujisaki, Joji, Silberstein, Lev, Alexe, Gabriela, Al-Hajj, Muhammad A, Shelton, Christopher A, Armstrong, Scott A., Root, David E, Scadden, David T, Mukherjee, Siddhartha, Stegmaier, Kimberly, Jordan, Craig T, Ebert, Benjamin L., Hynes, Richard O
Published 2015

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

by Bandopadhayay, Pratiti, Piccioni, Federica, O'Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred Chiu-Lai, Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B, Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen
Published 2020