High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma

High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma

Cutaneous melanoma is an aggressive tumor that accounts for most skin cancer deaths. Among the physiological barriers against therapeutic success is a strong survival program driven by genes such as MITF that specify melanocyte identity, a phenomenon known in melanoma biology as lineage dependency....

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Main Authors: Eliades, Philip (Author), Abraham, Brian J. (Author), Ji, Zhenyu (Author), Christensen, Camilla L. (Author), Kwiatkowski, Nicholas (Author), Kumar, Raj (Author), Njauw, Ching Ni (Author), Taylor, Michael (Author), Miao, Benchun (Author), Zhang, Tinghu (Author), Wong, Kwok-Kin (Author), Gray, Nathanael S. (Author), Tsao, Hensin (Author), Young, Richard A. (Author), Miller, David M., III (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2019-01-22T19:22:12Z.
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