Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors

by Kalan, Sampada, Amat, Ramon, Schachter, Miriam Merzel, Kwiatkowski, Nicholas, Abraham, Brian J., Liang, Yanke, Zhang, Tinghu, Olson, Calla M., Larochelle, Stéphane, Gray, Nathanael S., Fisher, Robert P., Young, Richard A.
Published 2018

High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma

by Eliades, Philip, Abraham, Brian J., Ji, Zhenyu, Christensen, Camilla L., Kwiatkowski, Nicholas, Kumar, Raj, Njauw, Ching Ni, Taylor, Michael, Miao, Benchun, Zhang, Tinghu, Wong, Kwok-Kin, Gray, Nathanael S., Tsao, Hensin, Young, Richard A., Miller, David M., III
Published 2019

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

by Iniguez, Amanda Balboni, Stolte, Björn, Wang, Emily Jue, Conway, Amy Saur, Alexe, Gabriela, Dharia, Neekesh V., Kwiatkowski, Nicholas, Zhang, Tinghu, Abraham, Brian J., Mora, Jaume, Kalev, Peter, Leggett, Alan, Chowdhury, Dipanjan, Benes, Cyril H., Gray, Nathanael S., Stegmaier, Kimberly, Young, Richard A.
Published 2019

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

by Wang, Yubao, Zhang, Tinghu, Kwiatkowski, Nicholas, Abraham, Brian J, Lee, Tong Ihn, Xie, Shaozhen, Yuzugullu, Haluk, Von, Thanh, Li, Heyuan, Lin, Ziao, Stover, Daniel G, Lim, Elgene, Wang, Zhigang C, Iglehart, J. Dirk, Gray, Nathanael S, Zhao, Jean J, Young, Richard A.
Published 2017

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

by Olson, Calla M, Jiang, Baishan, Erb, Michael A, Liang, Yanke, Doctor, Zainab M, Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L, Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S, Bradner, James E, Winter, Georg E, Gray, Nathanael S, Young, Richard A.
Published 2018

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

by Zhang, Tinghu, Kwiatkowski, Nicholas, Olson, Calla M, Dixon-Clarke, Sarah E, Abraham, Brian J, Greifenberg, Ann K, Ficarro, Scott B, Elkins, Jonathan M, Liang, Yanke, Hannett, Nancy M, Manz, Theresa, Hao, Mingfeng, Bartkowiak, Bartlomiej, Greenleaf, Arno L, Marto, Jarrod A, Geyer, Matthias, Bullock, Alex N, Gray, Nathanael S, Young, Richard A.
Published 2017

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

by Liu, Qingsong, Xu, Chunxiao, Kirubakaran, Sivapriya, Zhang, Xin, Hur, Wooyoung, Kwiatkowski, Nicholas P., Wang, Jinhua, Westover, Kenneth D., Gao, Peng, Ercan, Dalia, Niepel, Mario, Thoreen, Carson C., Kang, Seong A., Patricelli, Matthew P., Wang, Yuchuan, Tupper, Tanya, Altabef, Abigail, Kawamura, Hidemasa, Held, Kathryn D., Chou, Danny M., Elledge, Stephen J., Janne, Pasi A., Wong, Kwok-Kin, Gray, Nathanael S., Sabatini, David, Liu, Yan
Published 2015

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

by Kwiatkowski, Nicholas P., Zhang, Tinghu, Rahl, Peter B., Abraham, Brian J., Reddy, Jessica, Ficarro, Scott B., Dastur, Anahita, Amzallag, Arnaud, Ramaswamy, Sridhar, Tesar, Bethany, Jenkins, Catherine E., Hannett, Nancy M., McMillin, Douglas, Sanda, Takaomi, Sim, Taebo, Kim, Nam Doo, Look, A. Thomas, Mitsiades, Constantine S., Weng, Andrew P., Brown, Jennifer R., Benes, Cyril H., Marto, Jarrod A., Young, Richard A., Gray, Nathanael S.
Published 2015

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression

by Rusan, Maria, Li, Kapsok, Li, Yvonne, Christensen, Camilla L., Abraham, Brian J., Kwiatkowski, Nicholas, Buczkowski, Kevin A., Bockorny, Bruno, Chen, Ting, Li, Shuai, Rhee, Kevin, Zhang, Haikuo, Chen, Wankun, Terai, Hideki, Tavares, Tiffany, Leggett, Alan L., Li, Tianxia, Wang, Yichen, Zhang, Tinghu, Kim, Tae-Jung, Hong, Sook-Hee, Poudel-Neupane, Neermala, Silkes, Michael, Mudianto, Tenny, Tan, Li, Shimamura, Takeshi, Meyerson, Matthew, Bass, Adam J., Watanabe, Hideo, Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin, Hammerman, Peter S.
Published 2019