Coactivator condensation at super-enhancers links phase separation and gene control

Coactivator condensation at super-enhancers links phase separation and gene control

Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity. Here we demonstrate that the SE-enriched transcriptional coactivators BRD4 and MED1 form nuclear punc...

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Main Authors: Sabari, Benjamin R. (Author), Dall'Agnese, Alessandra (Author), Boija, Ann (Author), Klein, Isaac A. (Author), Abraham, Brian J. (Author), Hannett, Nancy M. (Author), Guo, Yang E. (Author), Day, Daniel S. (Author), Schuijers, Jurian (Author), Hnisz, Denes (Author), Lee, Tong Ihn (Author), Coffey, Eliot Leo (Contributor), Shrinivas, Krishna (Contributor), Zamudio Montes de Oca, Alicia (Contributor), Manteiga, John Colonnese (Contributor), Li, Charles Han (Contributor), Vasile, Eliza (Contributor), Cisse, Ibrahim I (Contributor), Chakraborty, Arup K (Contributor), Sharp, Phillip A. (Author), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sharp, Phillip A (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2019-03-14T17:59:34Z.
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