Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut

Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut

Phase variation, the reversible alternation between genetic states, enables infection by pathogens and colonization by commensals. However, the diversity of phase variation remains underexplored. We developed the PhaseFinder algorithm to quantify DNA inversion-mediated phase variation. A systematic...

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Main Authors: Jiang, Xiaofang (Author), Hall, A. Brantley (Author), Arthur, Timothy D. (Author), Plitchta, Damian R. (Author), Covington, Christian T. (Author), Poyet, Mathilde (Author), Crothers, Jessica (Author), Moses, Peter L. (Author), Tolonen, Andrew C. (Author), Vlamakis, Hera (Author), Alm, Eric J. (Author), Xavier, Ramnik J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2020-04-30T17:46:59Z.
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