Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. However, the mechanisms for its action, and ultimately for resistance, have not been fully defined. Here, using a combination of expression profiling, genome-scale CRISPR/Cas9-mediated loss of functio...

Full description

Bibliographic Details
Main Authors: Bandopadhayay, Pratiti (Author), Piccioni, Federica (Author), O'Rourke, Ryan (Author), Ho, Patricia (Author), Gonzalez, Elizabeth M. (Author), Buchan, Graham (Author), Qian, Kenin (Author), Gionet, Gabrielle (Author), Girard, Emily (Author), Coxon, Margo (Author), Rees, Matthew G. (Author), Brenan, Lisa (Author), Dubois, Frank (Author), Shapira, Ofer (Author), Greenwald, Noah F. (Author), Pages, Melanie (Author), Balboni Iniguez, Amanda (Author), Paolella, Brenton R. (Author), Meng, Alice (Author), Sinai, Claire (Author), Roti, Giovanni (Author), Dharia, Neekesh V. (Author), Creech, Amanda (Author), Tanenbaum, Benjamin (Author), Khadka, Prasidda (Author), Tracy, Adam (Author), Tiv, Hong L. (Author), Hong, Andrew L. (Author), Coy, Shannon (Author), Rashid, Rumana (Author), Lin, Jia-Ren (Author), Cowley, Glenn S. (Author), Lam, Fred Chiu-Lai (Author), Goodale, Amy (Author), Lee, Yenarae (Author), Schoolcraft, Kathleen (Author), Vazquez, Francisca (Author), Hahn, William C. (Author), Tsherniak, Aviad (Author), Bradner, James E. (Author), Yaffe, Michael B (Author), Milde, Till (Author), Pfister, Stefan M. (Author), Qi, Jun (Author), Schenone, Monica (Author), Carr, Steven A. (Author), Ligon, Keith L. (Author), Kieran, Mark W. (Author), Santagata, Sandro (Author), Olson, James M. (Author), Gokhale, Prafulla C. (Author), Jaffe, Jacob D. (Author), Root, David E. (Author), Stegmaier, Kimberly (Author), Johannessen, Cory M. (Author), Beroukhim, Rameen (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-05-21T15:17:55Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items