Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches. Efforts such as The Cancer Genome Atlas Project will identify genes with aberrant copy number, sequence, or expression in various cancer types, prov...

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Main Authors: Ren, Yin (Contributor), Meyerson, Matthew L. (Contributor), Drapkin, Ronny (Contributor), Cheung, Hiu Wing (Author), Cowley, Glenn S. (Author), Weir, Barbara A. (Author), Boehm, Jesse S. (Author), Rusin, Scott (Author), Scott, Justine A. (Author), East, Alexandra (Author), Ali, Levi D. (Author), Lizotte, Patrick H. (Author), Wong, Terence C. (Author), Jiang, Guozhi (Author), Hsiao, Jessica (Author), Mermel, Craig H. (Author), Getz, Gad (Author), Barretina, Jordi (Author), Gopal, Shuba (Author), Tamayo, Pablo (Author), Gould, Joshua (Author), Tsherniak, Aviad (Author), Stransky, Nicolas (Author), Luo, Biao (Author), Mesirov, Jill P. (Author), Garraway, Levi A. (Author), Lander, Eric S. (Author), Root, David E. (Author), Hahn, William C. (Author), Bhatia, Sangeeta N (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Lander, Eric Steven (Contributor), Bhatia, Sangeeta N. (Contributor)
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences (PNAS), 2012-02-01T22:33:44Z.
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