mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts b...

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Main Authors: Katajisto, Pekka (Contributor), Lamming, Dudley W. (Contributor), Gultekin, Yetis (Contributor), Bauer-Rowe, Khristian E. (Contributor), Sengupta, Shomit (Contributor), Birsoy, Kivanc (Contributor), Dursun, Abdulmetin (Author), Yilmaz, V. Onur (Contributor), Selig, Martin (Author), Nielson, G. Petur (Author), Mino-Kenudson, Mari (Author), Zuckerberg, Lawrence (Author), Bahn, Atul K. (Author), Deshpande, Vikram (Author), Yilmaz, Omer (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor), Yilmaz, Omer H. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2012-12-18T21:26:50Z.
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