Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood [1, 2]. Using a metabolomics approach with isotope labeling, we found that in some cancer cells a relatively large amount...

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Main Authors: Locasale, Jason W. (Author), Grassian, Alexandra R. (Author), Melman, Tamar (Author), Lyssiotis, Costas A. (Author), Mattaini, Katherine Ruth (Contributor), Bass, Adam J. (Author), Heffron, Gregory J. (Author), Metallo, Christian M. (Contributor), Muranen, Taru (Author), Sharfi, Hadar (Author), Sasaki, Atsuo T. (Author), Anastasiou, Dimitrios (Author), Mullarky, Edouard (Author), Vokes, Natalie I. (Contributor), Sasaki, Mika (Author), Beroukhim, Rameen (Author), Stephanopoulos, Gregory (Contributor), Ligon, Azra H. (Author), Meyerson, Matthew L. (Author), Richardson, Andrea L. (Author), Chin, Lynda (Author), Wagner, Gerhard (Author), Asara, John M. (Author), Brugge, Joan S. (Author), Cantley, Lewis C. (Author), Vander Heiden, Matthew G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Vander Heiden, Matthew (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-01-18T15:55:32Z.
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