Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles
Plant-derived Type I toxins are candidate anticancer therapeutics requiring cytosolic delivery into tumor cells. We tested a concept for two-stage delivery, whereby tumor cells precoated with an antibody-targeted gelonin toxin were killed by exposure to endosome-disrupting polymer nanoparticles. Co-...
Main Authors: | , , , |
---|---|
Other Authors: | , , , , , |
Format: | Article |
Language: | English |
Published: |
American Chemical Society,
2013-08-02T17:23:07Z.
|
Subjects: | |
Online Access: | Get fulltext |