Immunopaleontology reveals how affinity enhancement is achieved during affinity maturation of antibodies to influenza virus
The Abs made by B lymphocytes on first encountering an antigen bind it with low intrinsic affinity, and, over time, the average affinity of the Abs made against that antigen gradually increases. These changes, known as affinity maturation, were found initially for serum antibodies that recognized sm...
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Bibliographic Details
| Main Authors: |
Eisen, Herman N.
(Contributor),
Chakraborty, Arup K
(Author) |
|---|
| Other Authors: |
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
(Contributor),
Massachusetts Institute of Technology. Department of Biological Engineering
(Contributor),
Massachusetts Institute of Technology. Department of Biology
(Contributor),
Massachusetts Institute of Technology. Department of Chemical Engineering
(Contributor),
Massachusetts Institute of Technology. Department of Chemistry
(Contributor),
Massachusetts Institute of Technology. Department of Physics
(Contributor),
Ragon Institute of MGH, MIT and Harvard
(Contributor),
Koch Institute for Integrative Cancer Research at MIT
(Contributor),
Chakraborty, Arup K.
(Contributor) |
|---|
| Format: | Article
|
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| Language: | English |
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| Published: |
National Academy of Sciences (U.S.),
2013-08-05T15:59:35Z.
|
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| Subjects: | |
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| Online Access: | Get fulltext
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