Spin models inferred from patient-derived viral sequence data faithfully describe HIV fitness landscapes

Spin models inferred from patient-derived viral sequence data faithfully describe HIV fitness landscapes

Mutational escape from vaccine-induced immune responses has thwarted the development of a successful vaccine against AIDS, whose causative agent is HIV, a highly mutable virus. Knowing the virus' fitness as a function of its proteomic sequence can enable rational design of potent vaccines, as t...

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Bibliographic Details
Main Authors: Shekhar, Karthik (Contributor), Ruberman, Claire (Author), Ferguson, Andrew L. (Author), Kardar, Mehran (Contributor), Barton, John P. (Contributor), Chakraborty, Arup K (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Chakraborty, Arup K. (Contributor)
Format: Article
Language:English
Published: American Physical Society, 2014-03-03T13:50:21Z.
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