Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

Intrinsic stress response pathways are frequently mobilized within tumor cells. The mediators of these adaptive mechanisms and how they contribute to carcinogenesis remain poorly understood. A striking example is heat shock factor 1 (HSF1), master transcriptional regulator of the heat shock response...

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Main Authors: Dai, Chengkai (Author), Santagata, Sandro (Author), Tang, Zijian (Author), Shi, Jiayuan (Author), Cao, Junxia (Author), Kwon, Hyoungtae (Author), Bronson, Roderick T. (Author), Whitesell, Luke (Author), Lindquist, Susan (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: American Society for Clinical Investigation, 2014-04-03T14:58:40Z.
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