HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival, and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tr...

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Bibliographic Details
Main Authors: Mendillo, Marc L. (Author), Santagata, Sandro (Author), Bell, George W. (Author), Hu, Rong (Author), Tamimi, Rulla M (Author), Fraenkel, Ernest (Contributor), Ince, Tan A. (Author), Whitesell, Luke (Author), Lindquist, Susan (Contributor), Koeva, Martina I (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koeva, Martina I. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-11-26T14:02:30Z.
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