Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs (hESCs) invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterp...

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Main Authors: Lengner, Christopher J. (Contributor), Gimelbrant, Alexander A. (Author), Erwin, Jennifer A. (Author), Cheng, Albert W. (Contributor), Guenther, Matthew G. (Contributor), Welstead, G. Grant (Contributor), Alagappan, Raaji (Contributor), Frampton, Garrett M. (Contributor), Xu, Ping (Contributor), Muffat, Julien (Contributor), Santagata, Sandro (Contributor), Powers, Doug (Author), Barrett, C. Brent (Author), Young, Richard A. (Contributor), Lee, Jeannie T. (Author), Jaenisch, Rudolf (Contributor), Mitalipova, Maisam (Contributor)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2015-04-03T14:30:42Z.
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