The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

Adaptor proteins link surface receptors to intracellular signaling pathways and potentially control the way cells respond to nutrient availability. Mice deficient in p66Shc, the most recently evolved isoform of the Shc1 adaptor proteins and a mediator of receptor tyrosine kinase signaling, display r...

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Main Authors: Lamming, Dudley W. (Contributor), Soliman, Mohamed A. (Author), Abdel Rahman, Anas M. (Author), Birsoy, Kivanc (Author), Pawling, Judy (Author), Frigolet, Maria E. (Author), Lu, Huogen (Author), Fantus, I. George (Author), Pasculescu, Adrian (Author), Zheng, Yong (Author), Dennis, James W. (Author), Pawson, Tony (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2015-04-23T18:37:59Z.
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