mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

The mTOR complex 1 (mTORC1) protein kinase is a master growth regulator that is stimulated by amino acids. Amino acids activate the Rag guanosine triphosphatases (GTPases), which promote the translocation of mTORC1 to the lysosomal surface, the site of mTORC1 activation. We found that the vacuolar H...

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Bibliographic Details
Main Authors: Zoncu, Roberto (Contributor), Bar-Peled, Liron (Contributor), Efeyan, Alejo (Contributor), Sancak, Yasemin (Contributor), Sabatini, David M. (Contributor), Wang, Shuyu, Ph. D. Massachusetts Institute of Technology (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Wang, Shuyu (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2015-04-24T18:27:40Z.
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