Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast

Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast

gp120 is a substrate for protein engineering both for human immunodeficiency virus (HIV) immunogen design and as a bait for isolating anti-HIV antibodies from patient samples. In this work, we describe the display of a stripped core gp120 on the yeast cell surface. Validation against a panel of neut...

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Bibliographic Details
Main Authors: Mata-Fink, Jordi (Contributor), Kriegsman, Barry (Contributor), Yu, Hui Xin (Contributor), Zhu, Hanna (Contributor), Wittrup, Karl Dane (Contributor), Hanson, Melissa Catherine (Author), Irvine, Darrell J (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hanson, Melissa C. (Contributor), Irvine, Darrell J. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-23T17:20:11Z.
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