Statistical tests for intra-tumour clonal co-occurrence and exclusivity

Statistical tests for intra-tumour clonal co-occurrence and exclusivity

Tumour progression is an evolutionary process in which different clones evolve over time, leading to intra-tumour heterogeneity. Interactions between clones can affect tumour evolution and hence disease progression and treatment outcome. Intra-tumoural pairs of mutations that are overrepresented in...

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Bibliographic Details
Main Authors: Beerenwinkel, N. (Author), Beisel, C. (Author), Futreal, P.A (Author), Jahn, K. (Author), Kuipers, J. (Author), Moch, H. (Author), Moore, A.L (Author), Morita, K. (Author), Schraml, P. (Author), Takahashi, K. (Author), Wang, F. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
acute myeloid leukemia
algorithm
Algorithms
analytical error
Article
base pairing
biology
calibration
cancer patient
classification
clonal evolution
cohort analysis
Computational Biology
controlled study
disease exacerbation
Disease Progression
evolution
gene identification
genetics
human
Humans
Leukemia, Myeloid, Acute
major clinical study
Models, Statistical
mutation
Mutation
pathology
power of a test
procedures
signal transduction
Signal Transduction
single cell RNA seq
statistical analysis
statistical model
tumor recurrence
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