Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation

by Benedetta Fois, Simona Distinto, Rita Meleddu, Serenella Deplano, Elias Maccioni, Costantino Floris, Antonella Rosa, Mariella Nieddu, Pierluigi Caboni, Claudia Sissi, Andrea Angeli, Claudiu T. Supuran, Filippo Cottiglia
Published 2020-01-01

1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy

by Barbara Kaproń, Robert Czarnomysy, Mariusz Wysokiński, Rudolf Andrys, Kamil Musilek, Andrea Angeli, Claudiu T. Supuran, Tomasz Plech
Published 2020-01-01

Use of an immobilised thermostable α-CA (SspCA) for enhancing the metabolic efficiency of the freshwater green microalga Chlorella sorokiniana

by Giovanna Salbitani, Sonia Del Prete, Francesco Bolinesi, Olga Mangoni, Viviana De Luca, Vincenzo Carginale, William A. Donald, Claudiu T. Supuran, Simona Carfagna, Clemente Capasso
Published 2020-01-01

The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cells

by Silvia Peppicelli, Elena Andreucci, Jessica Ruzzolini, Francesca Bianchini, Chiara Nediani, Claudiu T. Supuran, Lido Calorini
Published 2020-01-01

Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

by Ashok Aspatwar, Emanuela Berrino, Silvia Bua, Fabrizio Carta, Clemente Capasso, Seppo Parkkila, Claudiu T. Supuran
Published 2020-01-01

Inhibitory activity against carbonic anhydrase IX and XII as a candidate selection criterion in the development of new anticancer agents

by Mikhail Krasavin, Stanislav Kalinin, Tatiana Sharonova, Claudiu T. Supuran
Published 2020-01-01

Inhibition survey with phenolic compounds against the δ- and η-class carbonic anhydrases from the marine diatom thalassiosira weissflogii and protozoan Plasmodium falciparum

by Siham A. Alissa, Hanan A. Alghulikah, Zeid A. ALOthman, Sameh M. Osman, Sonia Del Prete, Clemente Capasso, Alessio Nocentini, Claudiu T. Supuran
Published 2020-01-01

Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis

by Linda J. Urbański, Anna Di Fiore, Latifeh Azizi, Vesa P. Hytönen, Marianne Kuuslahti, Martina Buonanno, Simona M. Monti, Andrea Angeli, Reza Zolfaghari Emameh, Claudiu T. Supuran, Giuseppina De Simone, Seppo Parkkila
Published 2020-01-01

Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors

by Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hany E. A. Ahmed, Sivia Bua, Alessio Nocentini, Nawaf A. AlSaif, Ahmad J. Obaidullah, Mohamed M. Hefnawy, Claudiu T. Supuran
Published 2020-01-01

Aryl derivatives of 3H-1,2-benzoxathiepine 2,2-dioxide as carbonic anhydrase inhibitors

by Aleksandrs Pustenko, Alessio Nocentini, Anastasija Balašova, Ahmed Alafeefy, Mikhail Krasavin, Raivis Žalubovskis, Claudiu T. Supuran
Published 2020-01-01

A class of carbonic anhydrase IX/XII – selective carboxylate inhibitors

by Rakia Abd Alhameed, Emanuela Berrino, Zainab Almarhoon, Ayman El-Faham, Claudiu T. Supuran
Published 2020-01-01

A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors

by Manuel A. Llanos, María L. Sbaraglini, María L. Villalba, María D. Ruiz, Carolina Carrillo, Catalina Alba Soto, Alan Talevi, Andrea Angeli, Seppo Parkkila, Claudiu T. Supuran, Luciana Gavernet
Published 2020-01-01

Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scann...

by Mikhail Krasavin, Stanislav Kalinin, Sergey Zozulya, Anastasia Griniukova, Petro Borysko, Andrea Angeli, Claudiu T. Supuran
Published 2020-01-01

Bioorganometallic derivatives of 4-hydrazino-benzenesulphonamide as carbonic anhydrase inhibitors: synthesis, characterisation and biological evaluation

by Jeremie Brichet, Rodrigo Arancibia, Emanuela Berrino, Claudiu T. Supuran
Published 2020-01-01

7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors

by Aleksandrs Pustenko, Alessio Nocentini, Anastasija Balašova, Mikhail Krasavin, Raivis Žalubovskis, Claudiu T. Supuran
Published 2020-01-01

Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

by Yazgı Dizdaroglu, Canan Albay, Tayfun Arslan, Abdulilah Ece, Emir A. Turkoglu, Asiye Efe, Murat Senturk, Claudiu T. Supuran, Deniz Ekinci
Published 2020-01-01

Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile

by Nabih Lolak, Mehmet Boga, Muhammed Tuneg, Gulcin Karakoc, Suleyman Akocak, Claudiu T. Supuran
Published 2020-01-01

Preparation, carbonic anhydrase enzyme inhibition and antioxidant activity of novel 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives incorporating mono or dipeptide moiety

by Hasan Küçükbay, Zeynep Gönül, F. Zehra Küçükbay, Andrea Angeli, Gianluca Bartolucci, Claudiu T. Supuran
Published 2020-01-01

Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation

by Paolo Guglielmi, Giulia Rotondi, Daniela Secci, Andrea Angeli, Paola Chimenti, Alessio Nocentini, Alessandro Bonardi, Paola Gratteri, Simone Carradori, Claudiu T. Supuran
Published 2020-01-01

Activation studies of the β-carbonic anhydrases from Escherichia coli with amino acids and amines

by Alessio Nocentini, Sonia Del Prete, Margaret D. Mastrolorenzo, William A. Donald, Clemente Capasso, Claudiu T. Supuran
Published 2020-01-01