2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

by Walsh, Martin J., Brimacombe, Kyle R., Veith, Henrike, Bougie, James M., Daniel, Thomas, Leister, William, Cantley, Lewis C., Vander Heiden, Matthew G., Shen, Min, Auld, Douglas S., Thomas, Craig J., Boxer, Matthew B., Israelsen, William James
Published 2015

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

by Muir, Alexander, Danai, Laura V., Vander Heiden, Matthew G.
Published 2019

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

by Vander Heiden, Matthew G., Anastasiou, Dimitrios, Poulogiannis, George, Asara, John M., Boxer, Matthew B., Jiang, Jian-kang, Shen, Min, Gary, Bellinger, Sasaki, Atsuo T., Locasale, Jason W., Auld, Douglas S., Thomas, Craig J., Cantley, Lewis C., Bellinger, Gary
Published 2013

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

by Olivares, Orianne, Mayers, Jared R., Gouirand, Victoire, Torrence, Margaret E., Gicquel, Tristan, Borge, Laurence, Lac, Sophie, Roques, Julie, Lavaut, Marie-Noëlle, Berthezène, Patrice, Rubis, Marion, Secq, Veronique, Garcia, Stéphane, Moutardier, Vincent, Lombardo, Dominique, Iovanna, Juan Lucio, Tomasini, Richard, Guillaumond, Fabienne, Vander Heiden, Matthew G., Vasseur, Sophie
Published 2018

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

by Düvel, Katrin, Yecies, Jessica L., Menon, Suchithra, Raman, Pichai, Triantafellow, Ellen, Ma, Qicheng, Gorski, Regina, Cleaver, Stephen, MacKeigan, Jeffrey P., Finan, Peter M., Murphy, Leon O., Manning, Brendan D., Lipovsky, Alex, Souza, Amanda, Vander Heiden, Matthew G., Clish, Clary
Published 2018

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1

by Vander Heiden, Matthew G.
Published 2020

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival

by Yi, Caroline H, Pan, Heling, Seebacher, Jan, Jang, Il-Ho, Hyberts, Sven G, Heffron, Gregory J., Vander Heiden, Matthew G, Yang, Renliang, Li, Fupeng, Locasale, Jason W., Sharfi, Hadar, Zhai, Bo, Rodriguez-Mias, Ricard, Luithardt, Harry, Cantley, Lewis C., Daley, George Q., Asara, John M., Gygi, Steven P., Wagner, Gerhard, Liu, Chuan-Fa, Yuan, Junying
Published 2014

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

by Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Chan, Sze Ham, Freinkman, Elizaveta, Lewis, Caroline A., Vander Heiden, Matthew G.
Published 2020

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

by McBrayer, Samuel K., Mayers, Jared R., DiNatale, Gabriel J., Shi, Diana D., Khanal, Januka, Chakraborty, Abhishek A., Sarosiek, Kristopher A., Briggs, Kimberly J., Robbins, Alissa K., Sewastianik, Tomasz, Shareef, Sarah J., Olenchock, Benjamin A., Parker, Seth J., Tateishi, Kensuke, Spinelli, Jessica B., Islam, Mirazul, Haigis, Marcia C., Looper, Ryan E., Ligon, Keith L., Bernstein, Bradley E., Carrasco, Ruben D., Cahill, Daniel P., Asara, John M., Metallo, Christian M., Yennawar, Neela H., Vander Heiden, Matthew G., Kaelin, William G.
Published 2020

Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

by Andronesi, Ovidiu C., Kim, Grace S., Gerstner, Elizabeth R., Batchelor, Tracy T., Tzika, Aria A., Fantin, Valeria R., Vander Heiden, Matthew G., Sorensen, A. Gregory
Published 2014

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

by Garcia-Cao, Isabel, Song, Min Sup, Hobbs, Robin M, Laurent, Gaelle, Giorgi, Carlotta, de Boer, Vincent C. J., Anastasiou, Dimitrios, Ito, Keisuke, Sasaki, Atsuo T, Rameh, Lucia, Carracedo, Arkaitz, Vander Heiden, Matthew G, Cantley, Lewis C., Pinton, Paolo, Haigis, Marcia C., Pandolfi, Pier Paolo, Vander Heiden, Matthew G.
Published 2014

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

by Freinkman, Elizaveta, Thomas, Craig J., Gui, Dan Yi, Sullivan, Lucas Bryan, Luengo, Alba, Hosios, Aaron Marc, Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M, Vander Heiden, Matthew G.
Published 2018

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

by Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Miller, G., Drebin, J. A., Bar-Sagi, D., Thompson, C. B., Rabinowitz, J. D., Vander Heiden, Matthew G.
Published 2016

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

by Hu, Jie, Locasale, Jason W., Bielas, Jason H., O'Sullivan, Jacintha, Sheahan, Kieran, Cantley, Lewis C., Vander Heiden, Matthew G., Vitkup, Dennis
Published 2014

Increased PHGDH expression promotes aberrant melanin accumulation

by Mattaini, Katherine R., Sullivan, Mark R., Lau, Allison N., Fiske, Brian P., Vander Heiden, Matthew G.
Published 2020

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

by Grassian, A. R., Parker, S. J., Divakaruni, A. S., Green, C. R., Zhang, X., Slocum, K. L., Pu, M., Lin, F., Vickers, C., Joud-Caldwell, C., Chung, F., Yin, H., Handly, E. D., Straub, C., Growney, J. D., Murphy, A. N., Pagliarini, R., Metallo, C. M., Davidson, Shawn M, Vander Heiden, Matthew G.
Published 2016

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

by Sullivan, Mark Robert, Mattaini, Katherine Ruth, Dennstedt, Emily A, Nguyen, Anna, Sivanand, Sharanya, Reilly, Montana F., Meeth, Katrina, Muir, Alexander, Darnell, Alicia, Bosenberg, Marcus W., Lewis, Caroline A., Vander Heiden, Matthew G.
Published 2020

Metabolic Pathway Alterations that Support Cell Proliferation

by Vander Heiden, Matthew G., Lunt, Sophia Yunkyungkwon, Dayton, Talya Lucia, Fiske, Brian Prescott, Israelsen, William James, Mattaini, Katherine Ruth, Vokes, N. I., Stephanopoulos, G., Cantley, Lewis C., Metallo, Christian M., Locasale, Jason W.
Published 2013

Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation

by Tech, Katherine, Tikunov, Andrey P., Farooq, Hamza, Morrissy, A. Sorana, Meidinger, Jessica, Fish, Taylor, Green, Sarah C., Liu, Hedi, Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M, Marra, Marco A., Vander Heiden, Matthew G., Taylor, Michael D., Macdonald, Jeffrey M., Gershon, Timothy R.
Published 2018

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

by Dayton, Talya L., Miller, Kathryn M., Bronson, Roderick T., Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn, Bhutkar, Arjun, Chidley, Caroline, Vander Heiden, Matthew G., Jacks, Tyler E.
Published 2018