mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis

by Laplante, Mathieu, Sabatini, David
Published 2011

The Multiple Roles of Cohesin in Meiotic Chromosome Morphogenesis and Pairing

by Brar, Gloria A., Ee, Ly-Sha, Hochwagen, Andreas, Amon, Angelika B
Published 2010

Transcription factor trapping by RNA in gene regulatory elements

by Sigova, A. A., Abraham, B. J., Ji, X., Molinie, B., Hannett, N. M., Guo, Y. E., Giallourakis, C. C., Jangi, Mohini Rohit, Sharp, Phillip A., Young, Richard A.
Published 2017

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

by Sabatini, David, Wolfson, Rachel Laura, Efeyan, Alejo
Published 2017

Nutrient-sensing mechanisms and pathways

by Efeyan, Alejo, Comb, William C., Sabatini, David
Published 2015

Nutrients versus growth factors in mTORC1 activation

by Efeyan, Alejo, Sabatini, David M, Sabatini, David
Published 2015

DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity

by Laplante, Mathieu, Horvat, Simon, Festuccia, William T., Birsoy, Kivanc, Prevorsek, Zala, Efeyan, Alejo, Sabatini, David M, Sabatini, David
Published 2014

Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treat...

by Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Ahmed, Tausif, Gray, Nathanael S., Sabatini, David
Published 2012

Amino acids and mTORC1: from lysosomes to disease

by Efeyan, Alejo, Zoncu, Roberto, Sabatini, David
Published 2017

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

by Wyant, Gregory A, Abu-Remaileh, Monther, Sabatini, David M.
Published 2020

Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in S. cerevisiae

by Liu, Qingsong, Ren, Tao, Fresques, Tara, Oppliger, Wolfgang, Niles, Brad J., Hur, Wooyoung, Hall, Michael N., Powers, Ted, Gray, Nathanael S., Sabatini, David
Published 2015

The TSC-mTOR pathway regulates macrophage polarization

by Byles, Vanessa, Covarrubias, Anthony J., Ben-Sahra, Issam, Lamming, Dudley W., Manning, Brendan D., Horng, Tiffany, Sabatini, David
Published 2015

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

by Wyant, Gregory A., Abu-Remaileh, Monther, Frenkel, Evgeni M., Laqtom, Nouf N., Dharamdasani, Vimisha, Lewis, Caroline A., Chan, Sze Ham, Sabatini, David M.
Published 2020

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

by Mihaylova, Maria M, Sabatini, David M, Yilmaz, Omer, Mihaylova, Maria M., Sabatini, David
Published 2016

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

by Freinkman, Elizaveta, Wang, Tim, Chen, Walter W., Abu-Remaileh, Monther, Sabatini, David, Birsoy, Kivanc
Published 2017

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

by Mercken, Evi M., Crosby, Seth D., Lamming, Dudley W., JeBailey, Lellean, Krzysik-Walker, Susan, Villareal, Dennis T., Capri, Miriam, Franceschi, Claudio, Zhang, Yongqing, Becker, Kevin, de Cabo, Rafael, Fontana, Luigi, Sabatini, David
Published 2015

Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of the Transcription Factors FoxA2, FoxO1, and SREBP1c

by Wan, Min, Leavens, Karla F, Saleh, Danish, Easton, Rachael M, Guertin, David A., Peterson, Timothy R, Kaestner, Klaus H., Sabatini, David M, Birnbaum, Morris J, Sabatini, David, Peterson, Timothy Richard
Published 2014

Perturbation-Expression Analysis Identifies RUNX1 as a Regulator of Human Mammary Stem Cell Differentiation

by Sanduja, Sandhya, Jin, Dexter X., Sokol, Ethan Samuel, Miller, Daniel Handel, Mathis, Robert Austin, Gupta, Piyush
Published 2015

Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program

by Kang, Seong Anthony Woo, Sabatini, David M.
Published 2020

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

by Bar-Peled, Liron, Zoncu, Roberto, Sabatini, David M, Schweitzer, Lawrence David, Sabatini, David
Published 2014