Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line

by Espelin, Christopher W., Goldsipe, Arthur C., Sorger, Peter K., Lauffenburger, Douglas A., de Graaf, David, Hendriks, Bart S.
Published 2012

Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation

by Kreeger, Pamela K., Wang, Yufang, Haigis, Kevin M., Lauffenburger, Douglas A
Published 2012

Efficient Bayesian estimates for discrimination among topologically different systems biology models

by Hagen, David Robert, Tidor, Bruce
Published 2015

Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions

by Naegle, Kristen Marie, White, Forest M., Lauffenburger, Douglas A., Yaffe, Michael B.
Published 2014

A microfluidic "baby machine" for cell synchronization

by Shaw, Josephine, Payer, Kristofor Robert, Son, Sungmin, Grover, William H., Manalis, Scott R
Published 2014

A multiscale-pore ion exchange membrane for better energy efficiency

by Lim, Geunbae, Kwon, Hyuckjin, Kim, Bumjoo, Han, Jongyoon
Published 2018

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

by Gianella, Anita, Mieszawska, Aneta J., Hoeben, Freek J. M., Janssen, Henk M., Jarzyna, Peter A., Cormode, David P., Costa, Kevin D., Rao, Satish, Farokhzad, Omid C., Langer, Robert, Fayad, Zahi A., Mulder, Willem J. M.
Published 2014

O[superscript 6]-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation

by Noonan, Ericka M., Shah, Dharini, Yaffe, Michael B, Lauffenburger, Douglas A, Samson, Leona D
Published 2014

Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes

by Wang, Yana, Irvine, Darrell J
Published 2014

Manganese displacement from Zinpyr-1 allows zinc detection by fluorescence microscopy and magnetic resonance imaging

by You, Youngmin, Tomat, Elisa, Hwang, Kevin, Atanasijevic, Tatjana, Nam, Wonwoo, Jasanoff, Alan Pradip, Lippard, Stephen J.
Published 2011

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α

by Lau, Ken S., Gierut, Jessica, Lauffenburger, Douglas A., Haigis, Kevin M., Schrier, Sarah, Lyons, Jesse Stolberg
Published 2015

Predicting cancer drug mechanisms of action using molecular network signatures

by Pritchard, Justin R., Bruno, Peter Michael, Hemann, Michael, Lauffenburger, Douglas A
Published 2014

A high-throughput microfluidic device to study neurite response to growth factor gradients

by Kothapalli, Chandrasekhar R., de Valence, Sarra, Chung, Seok, Zervantonakis, Ioannis, Gertler, Frank, Kamm, Roger Dale, Van Veen, John
Published 2012

Creating sub-50 nm nanofluidic junctions in a PDMS microchip via self-assembly process of colloidal silica beads for electrokinetic concentration of biomolecules

by Syed, A., Song, Y.-A, Mangano, Lauren M., Mao, Pan, Han, Joanna M.
Published 2017

Single-cell analysis of the dynamics and functional outcomes of interactions between human natural killer cells and target cells

by Berger, Christoph T., Sips, Magdalena, Cheney, Patrick C., Alter, Galit, Yamanaka, Yvonne J., Love, John C
Published 2013

Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines

by Adalsteinsson, Viktor A., Tahirova, Narmin, Tallapragada, Naren, Yao, Xiaosai, Campion, Liam, Angelini, Alessandro, Douce, Thomas B., Bowman, Brittany, Williamson, Christina A., Huang, Cindy Y., Kwon, Douglas, Wittrup, Karl Dane, Love, John C
Published 2014

Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

by Aref, Amir R., Huang, Ruby Yun-Ju, Yu, Weimiao, Chua, Kian-Ngiap, Sun, Wei, Tu, Ting-Yuan, Bai, Jing, Sim, Wen-Jing, Zervantonakis, Ioannis K., Thiery, Jean Paul, Kamm, Roger Dale
Published 2014

SAMNet: a network-based approach to integrate multi-dimensional high throughput datasets

by Spencer, Sarah J., Ursu, Oana, Fraenkel, Ernest, Gosline, Sara Jane Calafell
Published 2014

Structure of the EGF receptor transactivation circuit integrates with cell context

by Joslin, Elizabeth J., Shankaran, Harish, Opresko, Lee K., Bollinger, Nikki, Lauffenburger, Douglas A., Wiley, H. Steven
Published 2012

Protein Thin Film Machines

by Federici, Stefania, Oliviero, Giulio, Hamad-Schifferli, Kimberly, Bergese, Paolo
Published 2011