Rapamycin inhibits mTORC1, but not completely

by Thoreen, Carson C, Sabatini, David
Published 2012

Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treat...

by Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Ahmed, Tausif, Gray, Nathanael S., Sabatini, David
Published 2012

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapa...

by Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Markhard, Andrew L., Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Gray, Nathanael S., Sabatini, David
Published 2014

A unifying model for mTORC1-mediated regulation of mRNA translation

by Thoreen, Carson C., Chantranupong, Lynne, Wang, Tim, Gray, Nathanael S., Keys, Heather Rochelle, Sabatini, David
Published 2014

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

by Liu, Qingsong, Xu, Chunxiao, Kirubakaran, Sivapriya, Zhang, Xin, Hur, Wooyoung, Kwiatkowski, Nicholas P., Wang, Jinhua, Westover, Kenneth D., Gao, Peng, Ercan, Dalia, Niepel, Mario, Thoreen, Carson C., Kang, Seong A., Patricelli, Matthew P., Wang, Yuchuan, Tupper, Tanya, Altabef, Abigail, Kawamura, Hidemasa, Held, Kathryn D., Chou, Danny M., Elledge, Stephen J., Janne, Pasi A., Wong, Kwok-Kin, Gray, Nathanael S., Sabatini, David, Liu, Yan
Published 2015