Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

by DeKelver, Russell C., Choi, Vivian M., Moehle, Erica A., Paschon, David E., Hockemeyer, Dirk, Meijsing, Sebastiaan H., Sancak, Yasemin, Cui, Xiaoxia, Steine, Eveline J., Miller, Jeffrey C., Tam, Phillip, Bartsevich, Victor V., Meng, Xiangdong, Rupniewski, Igor, Gopalan, Sunita M., Sun, Helena C., Pitz, Kathleen J., Rock, Jeremy M., Davis, Gregory D., Rebar, Edward J., Yamamoto, Keith R., Jaenisch, Rudolf, Gregory, Philip D., Urnov, Fyodor D., Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014, Cheeseman, Iain M, Sabatini, David
Published 2012

CellProfiler Analyst: data exploration and analysis software for complex image-based screens

by Wheeler, Douglas B., Kang, In Han, Golland, Polina, Papallo, Adam, Lindquist, Robert A., Jones, Thouis R., Van Dyk, Anne Carpenter, Sabatini, David
Published 2009

Cooperative nutrient accumulation sustains growth of mammalian cells

by Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Weng, Yaochung, Wood, Kris, Vander Heiden, Matthew G., Hosios, Aaron Marc, Schweitzer, Lawrence David, Thoreen, Carson C, Sabatini, David, Manalis, Scott R
Published 2016

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

by Freinkman, Elizaveta, Comb, William C, Cantor, Jason R, Tam, Wai Leong, Thiru, Prathapan, Kanarek, Naama, Bierie, Brian, Shaul, Yoav, Kim, Dohoon, Chen, Walter W., Possemato, Richard, Reinhardt, Ferenc, Weinberg, Robert A, Yaffe, Michael B, Sabatini, David, Pacold, Michael Edward
Published 2017

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes

by Shen, Kuang, Bomaliyamu, Aimaiti, Hong, Chuan, Yu, Zhiheng, Huang, Rick, Brignole, Edward J, Condon, Kendall Janine, Valenstein, Max L., Chantranupong, Lynne, Choe, Abigail D., Sabatini, David
Published 2018

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

by Freinkman, Elizaveta, Birsoy, Kıvanç, Chen, Walter W., Wang, Tim, Sabatini, David
Published 2018

Response and Acquired Resistance to Everolimus in Anaplastic Thyroid Cancer

by Van Allen, Eliezer M., Amin-Mansour, Ali, Taylor-Weiner, Amaro, Rosenberg, Mara, Barletta, Justine A., Guo, Yanan, Swanson, Scott J., Ruan, Daniel T., Hanna, Glenn J., Haddad, Robert I., Kwiatkowski, David J., Jänne, Pasi A., Lorch, Jochen H., Wagle, Nikhil, Grabiner, Brian, Gray, Nathanael S, Getz, Gad Asher, Carter, Scott, Sabatini, David, Garraway, Levi A.
Published 2017

Growth signaling at the nexus of stem cell life and death

by Wood, Kris C., Sabatini, David
Published 2009

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

by Carpenter, Anne E., Jones, Thouis R., Lamprecht, Michael R., Clarke, Colin, Kang, In Han, Friman, Ola, Guertin, David A., Chang, Joo Han, Lindquist, Robert A., Moffat, Jason, Golland, Polina, Sabatini, David
Published 2010

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

by Saadatpour, Assieh, Hong, Sue-Jean, Pinello, Luca, Katz, Yarden, Lamming, Dudley W., Guo, Guoji, Bell, George W., Selig, Martin, Nielsen, G. Petur, Gupta, Nitin, Ferrone, Cristina R., Deshpande, Vikram, Yuan, Guo-Cheng, Orkin, Stuart H., Beyaz, Semir, Mana, Miyeko, Roper, Jatin, Kedrin, Dmitriy, Bauer-Rowe, Khristian E., Xifaras, Michael, Akkad, Adam, Arias, Erika, Shinagare, Shweta, Abu-Remaileh, Monther, Dogum, Rizkullah, Sabatini, David, Yilmaz, Omer, Mihaylova, Maria M.
Published 2017

MERAV: a tool for comparing gene expression across human tissues and cell types

by Shaul, Yoav D., Yuan, Bingbing, Thiru, Prathapan, Nutter-Upham, Andy, McCallum, Scott, Bell, George W., Lanzkron, Carolyn, Sabatini, David
Published 2017

Sestrin2 is a leucine sensor for the mTORC1 pathway

by Shen, K., Cantor, J. R., Wolfson, Rachel Laura, Chantranupong, Lynne, Saxton, Robert Andrew, Scaria, Sonia M., Sabatini, David
Published 2017

Rapamycin inhibits mTORC1, but not completely

by Thoreen, Carson C, Sabatini, David
Published 2012

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

by Shen, Kuang, Choe, Abigail D., Sabatini, David
Published 2018

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

by Wang, Tim, Wei, Jenny J., Sabatini, David, Lander, Eric Steven
Published 2015

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

by Saxton, Robert Andrew, Wolfson, Rachel Laura, Chantranupong, Lynne, Wang, Tim, Schwartz, Thomas, Sabatini, David, Knockenhauer, Kevin Edward, Pacold, Michael Edward
Published 2017

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

by Park, Ryan J, Koundakjian, Dylan, Hultquist, Judd F, Lamothe-Molina, Pedro, Monel, Blandine, Schumann, Kathrin, Yu, Haiyan, Krupzcak, Kevin M, Garcia-Beltran, Wilfredo, Piechocka-Trocha, Alicja, Krogan, Nevan J, Marson, Alexander, Hacohen, Nir, Walker, Bruce D, Wang, Tim, Sabatini, David, Lander, Eric Steven
Published 2018

A Radical Role for TOR in Longevity

by Lamming, Dudley W, Sabatini, David M, Sabatini, David
Published 2014

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

by Harper, J. Wade, Gygi, Steven P., Gu, Xin, Orozco Segrera, Jose, Saxton, Robert Andrew, Condon, Kendall Janine, Liu, Grace Yun, Krawczyk, Patrycja A., Scaria, Sonia M., Sabatini, David
Published 2019

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

by Chantranupong, Lynne, Orozco, Jose M, Scaria, Sonia M, Bar-Peled, Liron, Spooner, Eric, Isasa, Marta, Gygi, Steven P., Sabatini, David M, Wolfson, Rachel Laura, Saxton, Robert Andrew, Scaria, Sonia M., Sabatini, David
Published 2015