mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

by Zoncu, Roberto, Bar-Peled, Liron, Efeyan, Alejo, Sancak, Yasemin, Sabatini, David M., Wang, Shuyu, Ph. D. Massachusetts Institute of Technology
Published 2015

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

by DeKelver, Russell C., Choi, Vivian M., Moehle, Erica A., Paschon, David E., Hockemeyer, Dirk, Meijsing, Sebastiaan H., Sancak, Yasemin, Cui, Xiaoxia, Steine, Eveline J., Miller, Jeffrey C., Tam, Phillip, Bartsevich, Victor V., Meng, Xiangdong, Rupniewski, Igor, Gopalan, Sunita M., Sun, Helena C., Pitz, Kathleen J., Rock, Jeremy M., Davis, Gregory D., Rebar, Edward J., Yamamoto, Keith R., Jaenisch, Rudolf, Gregory, Philip D., Urnov, Fyodor D., Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014, Cheeseman, Iain M, Sabatini, David
Published 2012

CellProfiler Analyst: data exploration and analysis software for complex image-based screens

by Wheeler, Douglas B., Kang, In Han, Golland, Polina, Papallo, Adam, Lindquist, Robert A., Jones, Thouis R., Van Dyk, Anne Carpenter, Sabatini, David
Published 2009

Cooperative nutrient accumulation sustains growth of mammalian cells

by Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Weng, Yaochung, Wood, Kris, Vander Heiden, Matthew G., Hosios, Aaron Marc, Schweitzer, Lawrence David, Thoreen, Carson C, Sabatini, David, Manalis, Scott R
Published 2016

Growth signaling at the nexus of stem cell life and death

by Wood, Kris C., Sabatini, David
Published 2009

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

by Carpenter, Anne E., Jones, Thouis R., Lamprecht, Michael R., Clarke, Colin, Kang, In Han, Friman, Ola, Guertin, David A., Chang, Joo Han, Lindquist, Robert A., Moffat, Jason, Golland, Polina, Sabatini, David
Published 2010

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

by Floyd, Scott R., Pacold, Michael E., Huang, Qiuying, Clarke, Scott M., Rameseder, Jonathan, Lee, Michael J., Blake, Emily J., Fydrych, Anna, Ho, Richard, Del Rosario, Amanda M., Root, David E., Carpenter, Anne E., Hahn, William C., Sabatini, David M., Chen, Clark C., White, Forest M., Bradner, James E., Yaffe, Michael B., Lam, Fred Chiu-Lai, Cannell, Ian Gordon, Bryson, Bryan D., Greenberger, Benjamin Aaron, Chen, Grace, Maffa, Amanda D.
Published 2014

Genome-wide CRISPR screen for Zika virus resistance in human neural cells

by Li, Yun, Muffat, Julien, Omer Javed, Attya, Keys, Heather R., Lungjangwa, Tenzin, Bosch, Irene, Khan, Mehreen, Virgilio, Maria C., Gehrke, Lee, Sabatini, David M., Jaenisch, Rudolf
Published 2020

Rapamycin inhibits mTORC1, but not completely

by Thoreen, Carson C, Sabatini, David
Published 2012

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

by Wang, Tim, Wei, Jenny J., Sabatini, David, Lander, Eric Steven
Published 2015

A Radical Role for TOR in Longevity

by Lamming, Dudley W, Sabatini, David M, Sabatini, David
Published 2014

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

by Chantranupong, Lynne, Orozco, Jose M, Scaria, Sonia M, Bar-Peled, Liron, Spooner, Eric, Isasa, Marta, Gygi, Steven P., Sabatini, David M, Wolfson, Rachel Laura, Saxton, Robert Andrew, Scaria, Sonia M., Sabatini, David
Published 2015

mTOR and cancer: many loops in one pathway

by Efeyan, Alejo, Sabatini, David
Published 2012

A Central Role for mTOR in Lipid Homeostasis

by Lamming, Dudley W, Sabatini, David M, Lamming, Dudley W., Sabatini, David
Published 2016

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

by Plovanich, M. E., Straub, C., Sabatini, B. L., Tsun, Zhi-Yang, Wang, Shuyu, Wolfson, Rachel Laura, Shen, Kuang, Wyant, Gregory Andrew, Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William C., Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Kim, Choah, Park, Jiwon, Sabatini, David
Published 2015

Rag proteins regulate amino-acid-induced mTORC1 signalling

by Sancak, Yasemin, Sabatini, David
Published 2011

The TASCC of Secretion

by Zoncu, Roberto, Sabatini, David
Published 2013

An emerging role of mTOR in lipid biosynthesis

by Laplante, Mathieu, Sabatini, David
Published 2012

mTOR Signaling in Growth Control and Disease

by Laplante, Mathieu, Sabatini, David M, Sabatini, David
Published 2014

mTOR: from growth signal integration to cancer, diabetes and ageing

by Zoncu, Roberto, Efeyan, Alejo, Sabatini, David
Published 2012