Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism

by Schuijers, Jurian, Day, Daniel Sindt, Hnisz, Denes, Lee, Tong Ihn, Manteiga, John Colonnese, Weintraub, Abraham Selby, Zamudio Montes de Oca, Alicia, Young, Richard A.
Published 2018

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

by Iniguez, Amanda Balboni, Stolte, Björn, Wang, Emily Jue, Conway, Amy Saur, Alexe, Gabriela, Dharia, Neekesh V., Kwiatkowski, Nicholas, Zhang, Tinghu, Abraham, Brian J., Mora, Jaume, Kalev, Peter, Leggett, Alan, Chowdhury, Dipanjan, Benes, Cyril H., Gray, Nathanael S., Stegmaier, Kimberly, Young, Richard A.
Published 2019

c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification

by Abraham, Brian J., Young, Richard A.
Published 2020

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

by Olson, Calla M, Jiang, Baishan, Erb, Michael A, Liang, Yanke, Doctor, Zainab M, Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L, Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S, Bradner, James E, Winter, Georg E, Gray, Nathanael S, Young, Richard A.
Published 2018

Mediator and cohesin connect gene expression and chromatin architecture

by Kagey, Michael H., Newman, Jamie Jennifer, Bilodeau, Steve, Zhan, Ye, Orlando, David A., van Berkum, Nynke L., Ebmeier, Christopher C., Goossens, Jesse, Rahl, Peter B., Levine, Stuart S., Taatjes, Dylan J., Dekker, Job, Young, Richard A.
Published 2012

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

by Giraud, Matthieu, Yoshida, Hideyuki, Abramson, Jakub, Rahl, Peter B., Young, Richard A., Mathis, Diane, Benoist, Christophe
Published 2012

Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

by Lien, Wen-Hui, Guo, Xingyi, Polak, Lisa, Lawton, Lee N., Young, Richard A, Zheng, Deyou, Fuchs, Elaine
Published 2014

An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

by Mansour, M. R., Abraham, B. J., Anders, L., Berezovskaya, A., Gutierrez, A., Durbin, A. D., Etchin, J., Lawton, L., Sallan, S. E., Silverman, L. B., Loh, M. L., Hunger, S. P., Sanda, T., Look, A. T., Young, Richard A.
Published 2017

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

by Betancur, Paola A., Abraham, Brian J., Yiu, Ying Y., Willingham, Stephen B., Khameneh, Farnaz, Zarnegar, Mark, Kuo, Angera H., McKenna, Kelly, Kojima, Yoko, Leeper, Nicholas J., Ho, Po, Gip, Phung, Swigut, Tomek, Sherwood, Richard I., Clarke, Michael F., Somlo, George, Weissman, Irving L., Young, Richard A.
Published 2017

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

by Zhang, Tinghu, Kwiatkowski, Nicholas, Olson, Calla M, Dixon-Clarke, Sarah E, Abraham, Brian J, Greifenberg, Ann K, Ficarro, Scott B, Elkins, Jonathan M, Liang, Yanke, Hannett, Nancy M, Manz, Theresa, Hao, Mingfeng, Bartkowiak, Bartlomiej, Greenleaf, Arno L, Marto, Jarrod A, Geyer, Matthias, Bullock, Alex N, Gray, Nathanael S, Young, Richard A.
Published 2017

Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues

by Zhang, Liguo, Richards, Alexsia, Barrasa, M. Inmaculada, Hughes, Stephen H., Young, Richard A., Jaenisch, Rudolf
Published 2021

Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2

by Kanhere, Aditi, Viiri, Keijo, Araújo, Carla C., Rasaiyaah, Jane, Bouwman, Russell D., Pereira, C. Filipe, Brookes, Emily, Walker, Kimberly, Bell, George W., Pombo, Ana, Fisher, Amanda G., Young, Richard A., Jenner, Richard G., Whyte, Warren Anthony
Published 2015

The Transcription Factors T-bet and GATA-3 Control Alternative Pathways of T-cell Differentiation Through a Shared Set of Target Genes

by Young, Richard A., Jenner, Richard G., Townsend, Michael J., Jackson, Ian, Sun, Kaiming, Bouwman, Russell D., Glimcher, Laurie H., Lord, Graham M.
Published 2010

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

by Wang, Yubao, Zhang, Tinghu, Kwiatkowski, Nicholas, Abraham, Brian J, Lee, Tong Ihn, Xie, Shaozhen, Yuzugullu, Haluk, Von, Thanh, Li, Heyuan, Lin, Ziao, Stover, Daniel G, Lim, Elgene, Wang, Zhigang C, Iglehart, J. Dirk, Gray, Nathanael S, Zhao, Jean J, Young, Richard A.
Published 2017

Small genomic insertions form enhancers that misregulate oncogenes

by Hnisz, Denes, Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Abraham, Brian Joseph, Weintraub, Abraham Selby, Kwiatkowski, Nick, Li, Charles Han, Lee, Tong Ihn, Young, Richard A.
Published 2017

Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells

by Dejosez, M., Frampton, Garrett M., Whyte, W. A., Stratton, S. A., Barton, Michelle C., Gunaratne, P. H., Zwaka, T. P., Levine, Stuart S., Young, Richard A.
Published 2014

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions

by Ji, Xiong, Abraham, Brian J., Lee, Tong Ihn, Jaenisch, Rudolf, Bradner, James E., Young, Richard A., Dadon, Daniel Benjamin
Published 2015

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene

by Liu, X. Shawn, Wu, Hao, Krzisch, Marine, Wu, Xuebing, Graef, John, Muffat, Julien, Hnisz, Denes, Li, Charles Han, Yuan, Bingbing, Xu, Chuanyun, Li, Yun, Vershkov, Dan, Cacace, Angela, Young, Richard A., Jaenisch, Rudolf
Published 2020

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

by Li, Z, Abraham, B J, Berezovskaya, A, Farah, N, Liu, Y, Leon, T, Fielding, A, Tan, S H, Sanda, T, Weintraub, A S, Li, B, Shen, S, Zhang, J, Mansour, M R, Look, A T, Young, Richard A.
Published 2018

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

by Chaffer, Christine L, Marjanovic, Nemanja D, Lee, Tony, Bell, George, Kleer, Celina G, Reinhardt, Ferenc, D'Alessio, Ana C, Young, Richard A, Weinberg, Robert A, Young, Richard A., Weinberg, Robert A
Published 2016