Antibody Subclass and Glycosylation Shift Following Effective TB Treatment

by Patricia S. Grace, Patricia S. Grace, Sepideh Dolatshahi, Lenette L. Lu, Adam Cain, Fabrizio Palmieri, Linda Petrone, Sarah M. Fortune, Tom H. M. Ottenhoff, Douglas A. Lauffenburger, Delia Goletti, Simone A. Joosten, Galit Alter
Published 2021-07-01

Host Blood RNA Transcript and Protein Signatures for Sputum-Independent Diagnostics of Tuberculosis in Adults

by Dhanasekaran Sivakumaran, Dhanasekaran Sivakumaran, Christian Ritz, Christian Ritz, John Espen Gjøen, Mario Vaz, Sumithra Selvam, Tom H. M. Ottenhoff, Timothy Mark Doherty, Synne Jenum, Harleen M. S. Grewal, Harleen M. S. Grewal
Published 2021-02-01

Identification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and Quantification

by Harriet D. Gliddon, Harriet D. Gliddon, Myrsini Kaforou, Mary Alikian, Mary Alikian, Dominic Habgood-Coote, Chenxi Zhou, Tolu Oni, Suzanne T. Anderson, Suzanne T. Anderson, Andrew J. Brent, Andrew J. Brent, Amelia C. Crampin, Amelia C. Crampin, Amelia C. Crampin, Brian Eley, Brian Eley, Robert Heyderman, Florian Kern, Florian Kern, Paul R. Langford, Tom H. M. Ottenhoff, Martin L. Hibberd, Neil French, Neil French, Victoria J. Wright, Hazel M. Dockrell, Lachlan J. Coin, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Michael Levin
Published 2021-03-01

HIV-Infected Patients Developing Tuberculosis Disease Show Early Changes in the Immune Response to Novel Mycobacterium tuberculosis Antigens

by Noemi Rebecca Meier, Noemi Rebecca Meier, Manuel Battegay, Manuel Battegay, Tom H. M. Ottenhoff, Hansjakob Furrer, Johannes Nemeth, Nicole Ritz, Nicole Ritz, Nicole Ritz, Nicole Ritz
Published 2021-03-01

Selection of a Single Domain Antibody, Specific for an HLA-Bound Epitope of the Mycobacterial Ag85B Antigen

by Paola A. Ortega, Mayra Silva-Miranda, Mayra Silva-Miranda, Alfredo Torres-Larios, Eduardo Campos-Chávez, Kees C. L. C. M. Franken, Tom H. M. Ottenhoff, Juraj Ivanyi, Clara Espitia, Clara Espitia
Published 2020-10-01

Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups

by Mariateresa Coppola, Raquel Villar-Hernández, Krista E. van Meijgaarden, Irene Latorre, Beatriz Muriel Moreno, Esther Garcia-Garcia, Kees L. M. C. Franken, Cristina Prat, Zoran Stojanovic, Maria Luiza De Souza Galvão, Joan-Pau Millet, Josefina Sabriá, Adrián Sánchez-Montalva, Adrián Sánchez-Montalva, Antoni Noguera-Julian, Annemieke Geluk, Jose Domínguez, Tom H. M. Ottenhoff
Published 2020-02-01

Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis

by Rosalie Lubbers, Jayne S. Sutherland, Delia Goletti, Roelof A. de Paus, Coline H. M. van Moorsel, Marcel Veltkamp, Stefan M. T. Vestjens, Willem J. W. Bos, Willem J. W. Bos, Linda Petrone, Franca Del Nonno, Ingeborg M. Bajema, Karin Dijkman, Frank A. W. Verreck, Gerhard Walzl, Kyra A. Gelderman, Geert H. Groeneveld, Annemieke Geluk, Tom H. M. Ottenhoff, Simone A. Joosten, Leendert A. Trouw
Published 2018-10-01

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease

by Valentina Orlando, Valentina Orlando, Marco P. La Manna, Marco P. La Manna, Delia Goletti, Fabrizio Palmieri, Elena Lo Presti, Elena Lo Presti, Simone A. Joosten, Carmela La Mendola, Simona Buccheri, Tom H. M. Ottenhoff, Francesco Dieli, Francesco Dieli, Nadia Caccamo, Nadia Caccamo
Published 2018-05-01

Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana

by Ernest Adankwah, Christian Lundtoft, Alptekin Güler, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Ertan Mayatepek, Ellis Owusu-Dabo, Ellis Owusu-Dabo, Richard Odame Phillips, Richard Odame Phillips, Norman Nausch, Marc Jacobsen
Published 2019-07-01

Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish

by Jôsimar D. Moreira, Jôsimar D. Moreira, Bjørn E. V. Koch, Suzanne van Veen, Kimberley V. Walburg, Frank Vrieling, Tânia Mara Pinto Dabés Guimarães, Annemarie H. Meijer, Herman P. Spaink, Tom H. M. Ottenhoff, Mariëlle C. Haks, Matthias T. Heemskerk
Published 2020-02-01

A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis

by Noëmi R. Meier, Noëmi R. Meier, Marc Jacobsen, Tom H. M. Ottenhoff, Nicole Ritz, Nicole Ritz, Nicole Ritz
Published 2018-11-01

Impaired Immune Response to Primary but Not to Booster Vaccination Against Hepatitis B in Older Adults

by Birgit Weinberger, Mariëlle C. Haks, Roelof A. de Paus, Tom H. M. Ottenhoff, Tanja Bauer, Beatrix Grubeck-Loebenstein
Published 2018-05-01

A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts

by Fergal J. Duffy, Ethan Thompson, Katrina Downing, Sara Suliman, Harriet Mayanja-Kizza, Harriet Mayanja-Kizza, W. Henry Boom, Bonnie Thiel, January Weiner III, Stefan H. E. Kaufmann, Drew Dover, David L. Tabb, Hazel M. Dockrell, Tom H. M. Ottenhoff, Gerard Tromp, Thomas J. Scriba, Daniel E. Zak, Gerhard Walzl, the GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. Loxton, N. N. Chegou, S. Suliman, T. Scriba, H. Mahomed, M. Erasmus, O. Xasa, A. Veldsman, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong C, W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh
Published 2018-04-01

Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application

by Mariateresa Coppola, Susan J. F. van den Eeden, Naoko Robbins, Louis Wilson, Kees L. M. C. Franken, Linda B. Adams, Tom P. Gillis, Tom H. M. Ottenhoff, Annemieke Geluk
Published 2018-02-01

Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination

by Mariëlle C. Haks, Barbara Bottazzi, Valentina Cecchinato, Corinne De Gregorio, Giuseppe Del Giudice, Stefan H. E. Kaufmann, Antonio Lanzavecchia, David J. M. Lewis, Jeroen Maertzdorf, Alberto Mantovani, Alberto Mantovani, Federica Sallusto, Federica Sallusto, Marina Sironi, Mariagrazia Uguccioni, Mariagrazia Uguccioni, Tom H. M. Ottenhoff
Published 2017-11-01

Disparate Tuberculosis Disease Development in Macaque Species Is Associated With Innate Immunity

by Karin Dijkman, Richard A. W. Vervenne, Claudia C. Sombroek, Charelle Boot, Sam O. Hofman, Krista E. van Meijgaarden, Tom H. M. Ottenhoff, Clemens H. M. Kocken, Krista G. Haanstra, Michel P. M. Vierboom, Frank A. W. Verreck
Published 2019-11-01

Evidence for Highly Variable, Region-Specific Patterns of T-Cell Epitope Mutations Accumulating in Mycobacterium tuberculosis Strains

by Arunachalam Ramaiah, Soumya Nayak, Srabanti Rakshit, Abigail L. Manson, Thomas Abeel, Sivakumar Shanmugam, Pravat Nalini Sahoo, Anto Jesuraj Uday Kumar John, Jagadish Chandrabose Sundaramurthi, Sujatha Narayanan, George D'Souza, Paul von Hoegen, Tom H. M. Ottenhoff, Soumya Swaminathan, Ashlee M. Earl, Annapurna Vyakarnam, Annapurna Vyakarnam
Published 2019-02-01

Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome

by Fergal J. Duffy, January Weiner, Scott Hansen, David L. Tabb, Sara Suliman, Ethan Thompson, Jeroen Maertzdorf, Smitha Shankar, Gerard Tromp, Shreemanta Parida, Shreemanta Parida, Drew Dover, Michael K. Axthelm, Jayne S. Sutherland, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Louis J. Picker, Gerhard Walzl, Stefan H. E. Kaufmann, Daniel E. Zak, The GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. F. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. G. Loxton, N. N. Chegou, S. Suliman, T. Scriba, M. Fisher, H. Mahomed, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong, C. W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. M. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh
Published 2019-03-01

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

by Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams, TBVAC2020 Consortium, Warwick Britton, Jamie Triccas, Claudio Counoupas, Johan Grooten, Marie-Ange Demoitie, Marta Romano, Francoise Mascart, Peter Andersen, Claus Aagaard, Dennis Christensen, Morten Ruhwald, Thomas Lindenstrom, Olivier Neyrolles, Pierre Charneau, Christophe Guilhot, Antonio Peixoto, Martine Gilleron, Camille Locht, Roland Brosch, Genevieve Inchauspe, Stephane Leung Theung Long, Stefan Kaufmann, January Weiner, Jeroen Maertzdorf, Natalie Neuwenhuizen, Max Bastian, Steffen Stenger, Nadia Caccamo, Delia Goletti, Roberto Nisini, Sung Jae Shin, Hyejon Lee, Alex Sigal, Thomas Scriba, Gerhard Walzl, Andre Loxton, Robert Wilkinson, Pere-Joan Cardona, Cris Vilaplana, Carlos Martin, Dessi Marinova, Nacho Aguilo, François Spertini, Ruedi Aebersold, Etienne Caron, Daniel Pinschewer, Gennaro De Libero, Claire Anne Siegrist, Nicolas Collin, Christophe Barnier-Quer, Peter Sander, Frank Verreck, Tom Ottenhoff, Simone Joosten, Krista van Meijgaarden, Mariateresa Coppola, Annemieke Geluk, Nick Drager, Danielle Roordink, Jelle Thole, Yvonne Perrie, Marc Baird, Michael Levin, Hazel Dockrell, Steven Smith, Helen Fletcher, Gregory Bancroft, Ann Rawkins, Simon Clark, Mei Mei Ho, Helen McShane, Iman Satti, Elena Stylianou, Martin Vordermeier, Philip Hogarth
Published 2017-10-01

Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype

by Nadia Caccamo, Nadia Caccamo, Simone A. Joosten, Tom H. M. Ottenhoff, Francesco Dieli, Francesco Dieli
Published 2018-12-01