Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML

by F. Brauneck, F Haag, R. Woost, N. Wildner, E. Tolosa, A. Rissiek, G. Vohwinkel, J. Wellbrock, C. Bokemeyer, J. Schulze zur Wiesch, C. Ackermann, W. Fiedler
Published 2021-01-01

Prognostic value of the PrPC-ILK-IDO1 axis in the mesenchymal colorectal cancer subtype

by Alexandre Ghazi, Delphine Le Corre, Camilla Pilati, Julien Taieb, Thomas Aparicio, Audrey Didelot, Shoukat Dedhar, Claire Mulot, Karine Le Malicot, Fatima Djouadi, Aurélien de Reynies, Jean-Marie Launay, Pierre Laurent-Puig, Sophie Mouillet-Richard
Published 2021-01-01

Correlation between PD-L1 expression ON CTCs and prognosis of patients with cancer: a systematic review and meta-analysis

by Defeng Kong, Wen Zhang, Zhenrong Yang, Guoliang Li, Shujun Cheng, Kaitai Zhang, Lin Feng
Published 2021-01-01

PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunity

by Haiping Jiang, Haiqing Ni, Pan Zhang, Xiaoli Guo, Min Wu, Haoran Shen, Jie Wang, Weiwei Wu, Zhihai Wu, Jiazheng Ding, Rong Tang, Shuaixiang Zhou, Bingliang Chen, Michael Yu, Hua Jing, Junjian Liu
Published 2021-01-01

Early changes in the immune microenvironment of oral potentially malignant disorders reveal an unexpected association of M2 macrophages with oral cancer free survival

by Jebrane Bouaoud, Jean-Philippe Foy, Antonin Tortereau, Lucas Michon, Vincent Lavergne, Nicolas Gadot, Sandrine Boyault, Julie Valantin, Geneviève De Souza, Philippe Zrounba, Chloé Bertolus, Nathalie Bendriss-Vermare, Pierre Saintigny
Published 2021-01-01

Development of a novel gene signature to predict prognosis and response to PD-1 blockade in clear cell renal cell carcinoma

by Xiaomao Yin, Zaoyu Wang, Jianfeng Wang, Yunze Xu, Wen Kong, Jin Zhang
Published 2021-01-01

A bacterium-derived, cancer-associated immunopeptidome

by Claude Perreault, Pierre Thibault, Guido Kroemer
Published 2021-01-01

Tumor spread or siege immunity: dissemination to distant metastasis or not

by Gabriela Bindea, Bernhard Mlecnik, Jérôme Galon
Published 2021-01-01

Safety, Tolerability, and Long-Term Clinical Outcomes of an IL-15 analogue (N-803) Admixed with Bacillus Calmette-Guérin (BCG) for the Treatment of Bladder Cancer

by Charles J. Rosser, Sergei Tikhonenkov, Jeffrey W. Nix, Owen T.M. Chan, Irina Ianculescu, Sandeep Reddy, Patrick Soon-Shiong
Published 2021-01-01

Integrative evaluation of primary and metastatic lesion spectrum to guide anti-PD-L1 therapy of non-small cell lung cancer: results from two randomized studies

by Si-Cong Ma, Xin-Ran Tang, Li-Li Long, Xue Bai, Jian-Guo Zhou, Zhi-Jiao Duan, Jian Wang, Qiang John Fu, Hong-Bo Zhu, Xue-Jun Guo, Yan-Pei Zhang, Ze-Qin Guo, De-Hua Wu, Zhong-Yi Dong
Published 2021-01-01

Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients

by Kaifeng Jin, Yifan Cao, Yun Gu, Hanji Fang, Yuchao Fei, Jieti Wang, Xin Liu, Kunpeng Lv, Xudong He, Chao Lin, Hao Liu, He Li, Hongyong He, Ruochen Li, Heng Zhang, Jiejie Xu
Published 2021-01-01

Analysis of the tumor microenvironment and anti-tumor efficacy of subcutaneous vs systemic delivery of the bifunctional agent bintrafusp alfa

by Yohei Ozawa, Kristin C. Hicks, Christine M. Minnar, Karin M. Knudson, Jeffrey Schlom, Sofia R. Gameiro
Published 2021-01-01

PPARγ induces PD-L1 expression in MSS+ colorectal cancer cells

by Tobias Gutting, Veronika Hauber, Jens Pahl, Kay Klapproth, Wenyue Wu, Ioana Dobrota, Frank Herweck, Juliane Reichling, Laura Helm, Torsten Schroeder, Beifang Li, Philip Weidner, Tianzuo Zhan, Maximilian Eckardt, Johannes Betge, Sebastian Belle, Carsten Sticht, Timo Gaiser, Michael Boutros, Matthias P.A. Ebert, Adelheid Cerwenka, Elke Burgermeister
Published 2021-01-01

Evasion before invasion: Pre-cancer immunosurveillance

by Mihaela Angelova, Céline Mascaux, Jérôme Galon
Published 2021-01-01

Prognostic value of the baseline circulating T cell receptor β chain diversity in advanced lung cancer

by Jiaqi Wang, Zhixin Bie, Yajing Zhang, Lin Li, Yujie Zhu, Yi Zhang, Xin Nie, Ping Zhang, Gang Cheng, Xuebing Di, Xiaoguang Li, Shujun Cheng, Lin Feng
Published 2021-01-01

Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition

by Lucia Lione, Erika Salvatori, Adriana Petrazzuolo, Alice Massacci, Roberta Maggio, Antonella Conforti, Mirco Compagnone, Luigi Aurisicchio, Gennaro Ciliberto, Fabio Palombo
Published 2021-01-01

Construction of PD1/CD28 chimeric-switch receptor enhances anti-tumor ability of c-Met CAR-T in gastric cancer

by Cong Chen, Yan-Mei Gu, Fan Zhang, Zheng-Chao Zhang, Ya-Ting Zhang, Yi-Di He, Ling Wang, Ning Zhou, Fu-Tian Tang, Hong-Jian Liu, Yu-Min Li
Published 2021-01-01

PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy

by Christopher D. Zahm, Jena E Moseman, Lauren E. Delmastro, Douglas G. Mcneel
Published 2021-01-01

A novel multimeric IL15/IL15Rα-Fc complex to enhance cancer immunotherapy

by Hong Xu, Ilia N. Buhtoiarov, Hongfen Guo, Nai-Kong V. Cheung
Published 2021-01-01

CD80 expression is upregulated by TP53 activation in human cancer epithelial cells

by Melania Scarpa, Chiara Marchiori, Marco Scarpa, Ignazio Castagliuolo
Published 2021-01-01